Warburton E C, Aggleton J P, Muir J L
School of Psychology, University of Wales Cardiff, UK.
Eur J Neurosci. 1998 Feb;10(2):622-34. doi: 10.1046/j.1460-9568.1998.00074.x.
The ability of rats to learn the location of a hidden platform in a swim maze was compared in animals with excitotoxic lesions of the anterior or posterior (retrosplenial) cingulate cortex or radiofrequency lesions of the cingulum bundle or fimbria-fornix. Performance of this allocentric spatial task was unaffected by the posterior cingulate cortex lesions, while anterior cingulate cortex damage produced only a mild acquisition deficit. Transection of the fornix and lesions of the cingulum bundle produced similar patterns of impairment on initial acquisition, but the cingulum bundle lesions had less effect on reversal of the task. The results from the water maze, and from a subsequent T-maze alternation task, indicate that cingulum bundle lesions can produce a spatial deficit that is similar, but milder, to that observed after fornix transection. The results of the excitotoxic lesions suggest that previous studies examining conventional cingulate lesions may have been influenced by damage to adjacent fibre tracts, such as the cingulum bundle.
将前扣带回皮质或后扣带回皮质（压后皮质）进行兴奋性毒性损伤，或对扣带束或穹窿进行射频损伤的动物，与正常大鼠相比，其在游泳迷宫中学习隐藏平台位置的能力。这项以自我为中心的空间任务的表现不受后扣带回皮质损伤的影响，而前扣带回皮质损伤仅产生轻微的习得缺陷。穹窿横断和扣带束损伤在初始习得时产生相似的损伤模式，但扣带束损伤对任务反转的影响较小。水迷宫以及随后的T迷宫交替任务的结果表明，扣带束损伤可产生与穹窿横断后观察到的相似但较轻的空间缺陷。兴奋性毒性损伤的结果表明，之前研究传统扣带回损伤的研究可能受到了对相邻纤维束（如扣带束）损伤的影响。
