Guedea F, Van Limbergen E, Van den Bogaert W
Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, University Autonoma de Barcelona, Spain.
Eur J Cancer. 1994;30A(12):1757-60. doi: 10.1016/0959-8049(94)00324-x.
Esthesioneuroblastoma is an uncommon tumour of neural crest origin arising in the nasal cavity. This paper is a retrospective review of 7 patients with esthesioneuroblastoma treated at a single institution from May 1974 to July 1990. 5 patients were treated with radiation therapy alone and 2 patients were irradiated after surgical resection. No local or regional occurrence was observed in any patient at 6 months, or at 1, 3, 6, 11.5 and 12 years following treatment. One patient died of intercurrent disease 6 years after radiation therapy. 2 patients died of disease, 1 of distant metastasis at 6 months and the other patient of meningeal carcinomatosis and distant metastases 1 year after treatment. One patient is alive with distant metastases 1 year after treatment. None of the patients experienced significant complications of irradiation. High-dose irradiation (60 Gy or more) alone or in combination with resection is an effective local treatment modality for esthesioneuroblastoma.
嗅神经母细胞瘤是一种起源于神经嵴的罕见肿瘤，发生于鼻腔。本文是对1974年5月至1990年7月在单一机构接受治疗的7例嗅神经母细胞瘤患者的回顾性研究。5例患者仅接受放射治疗，2例患者在手术切除后接受放疗。治疗后6个月以及1年、3年、6年、11.5年和12年时，未观察到任何患者出现局部或区域复发。1例患者在放疗6年后死于并发疾病。2例患者死于疾病，1例在治疗后6个月死于远处转移，另1例在治疗后1年死于脑膜癌病和远处转移。1例患者在治疗后1年因远处转移存活。所有患者均未出现明显的放疗并发症。单独使用高剂量放疗（60 Gy或更高）或与手术切除联合使用是治疗嗅神经母细胞瘤的一种有效的局部治疗方式。
