Merle-Melet M, Bresler L, Didelot J P, Jehl F, Gerard A, Boissel P
Department of Infectious Diseases, Hospital University Center, Nancy, France.
J Exp Anim Sci. 1994 Nov;36(6):201-8.
The pig is probably one of the best mammalian models for studying the digestive functions and the biliary excretion of drugs because of the tight similarities with humans. Insertion of a T drain in the common bile duct after cholecystectomy in humans became uncommon because of surgical progress. For this reason, we developed a model using a bidirectional cannula to study the biliary secretion in the conscious Micropig Yucatan. We used this breed because of their ready availability and low stable weight. The surgical procedure was a double choledococholedocal fistula with a bypass on the main biliary duct, maintaining the continuous flow of bile into the duodenum through the sphincter of Oddi. This fistula remained effective for at least sixty days with normal hepatic biologic parameters. The development of our model could improve the biliary excretion study of drugs. Comparison of different routes of administration and interaction pharmacokinetic studies could also be studied in the same micropig, eliminating intersubject variations.
由于猪与人类极为相似，它可能是研究药物消化功能和胆汁排泄的最佳哺乳动物模型之一。由于外科手术的进展，人类胆囊切除术后在胆总管插入T形引流管已不常见。因此，我们开发了一种使用双向套管的模型，以研究清醒状态下的尤卡坦小型猪的胆汁分泌。我们选用这个品种是因为它们易于获得且体重稳定。手术过程是在胆总管上做一个双胆总管十二指肠瘘，并在主胆管上做一个旁路，通过奥迪括约肌保持胆汁持续流入十二指肠。这种瘘管在至少六十天内保持有效，肝脏生物学参数正常。我们模型的开发可以改善药物胆汁排泄的研究。不同给药途径的比较和相互作用药代动力学研究也可以在同一头小型猪身上进行，消除个体间差异。
