Kruys V, Huez G
Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode-Saint-Genèse, Belgium.
Biochimie. 1994;76(9):862-6. doi: 10.1016/0300-9084(94)90188-0.
Several messenger RNAs which are transiently expressed contain a conserved uridine-adenosine-rich sequence in their 3' untranslated region. Many of these mRNas encode cytokines, growth factors or oncoproteins. This UA-rich sequence is composed of several interpsersed repeats of the octanucleotide UUAUUUAU and plays a key role in the post-transcriptional regulation of these mRNAs. Known as instability determinants, these UA-rich elements can also strongly affect mRNA translational efficiency. In this report, we review the data which illustrate this translational regulation and give insight the underlying mechanism.
几种瞬时表达的信使核糖核酸在其3'非翻译区含有一个保守的富含尿苷-腺苷的序列。这些信使核糖核酸中的许多编码细胞因子、生长因子或癌蛋白。这个富含UA的序列由八核苷酸UUAUUUAU的几个散布重复序列组成，并在这些信使核糖核酸的转录后调控中起关键作用。这些富含UA的元件被称为不稳定决定因素，也能强烈影响信使核糖核酸的翻译效率。在本报告中，我们综述了说明这种翻译调控的数据，并深入探讨了其潜在机制。
