Nair T M, Kulkarni B D, Nagaraja V
Chemical Engineering Division, National Chemical Laboratory, Pune, India.
Biophys Chem. 1995 Feb;53(3):241-5. doi: 10.1016/0301-4622(94)00116-2.
Using the theoretical model for DNA bending we have analyzed the Mu mom promoter wild type and its mutant tin7 which showed differential binding to the RNA polymerase. We have demonstrated here the structural change as a result of the point mutation which may be responsible for the altered binding of RNA polymerase. Analysis using both sets of parameters essentially gives the same result.
利用DNA弯曲的理论模型，我们分析了Mu mom启动子野生型及其突变体tin7，它们对RNA聚合酶的结合存在差异。我们在此证明了点突变导致的结构变化，这可能是RNA聚合酶结合改变的原因。使用两组参数进行分析基本上得到了相同的结果。
