Vainio H, Pääkkönen R, Rönnholm K, Raunio V, Pelkonen O
Scand J Work Environ Health. 1976 Sep;2(3):147-51. doi: 10.5271/sjweh.2813.
Styrene oxide is multagenic, without metabolic activation, to S. typhimurium strains TA 1535 and TA 100, which have been devised to detect mutagens causing base-pair substitutions. Styrene seems to be mutagenic toward the same strains, but only after metabolic activation. The toxicity of both styrene and styrene oxide make the construction of reliable dose-response curves rather difficult. Diethylmaleate and 3,3,3-trichloropropene oxide enhanced the mutagenicity of styrene oxide in the presence of homogenate; this result indicates the participation of epoxide hydratase and glutathione S-oxide transferase in the metabolism of styrene oxide. These two chemicals did not influence the mutagenic activity of styrene. Styrene glycol and 4-tert-butyl-brenzcatechin were not mutagenic to any of the strains studied. Results show that further, more detailed experimental and, possibly, epidemiologic studies are warranted.
氧化苯乙烯在无代谢活化的情况下，对用于检测引起碱基对置换诱变剂的鼠伤寒沙门氏菌TA 1535和TA 100菌株具有多种致突变性。苯乙烯似乎对相同菌株具有致突变性，但仅在代谢活化后才会如此。苯乙烯和氧化苯乙烯的毒性使得构建可靠的剂量反应曲线相当困难。马来酸二乙酯和3,3,3 - 三氯环氧丙烷在匀浆存在下增强了氧化苯乙烯的致突变性；这一结果表明环氧水解酶和谷胱甘肽S - 氧化物转移酶参与了氧化苯乙烯的代谢。这两种化学物质不影响苯乙烯的致突变活性。苯乙二醇和4 - 叔丁基邻苯二酚对所研究的任何菌株均无致突变性。结果表明，有必要进行进一步、更详细的实验研究以及可能的流行病学研究。
