沙门氏菌测试系统中苯乙烯的致突变性。
Mutagenicity of styrene in the Salmonella typhimurium test system.
作者信息
de Meester C, Duverger-van Bogaert M, Lambotte-Vandepaer M, Mercier M, Poncelet F
出版信息
Mutat Res. 1981 Dec;90(4):443-50. doi: 10.1016/0165-1218(81)90066-5.
The mutagenic activity of styrene was investigated by incubating the strains of Salmonella typhimurium in gaseous atmospheres. The sensitive strains were TA1530, TA1535 and TA100. In that method, styrene regularly showed a mutagenic activity in the presence of a fortified liver post-mitochondrial fraction. The mutagenic activity remained weak. Moreover, it seemed that a volatile mutagenic intermediate was formed metabolically during the assays; its identity remains unknown.
通过在气态环境中培养鼠伤寒沙门氏菌菌株来研究苯乙烯的致突变活性。敏感菌株为TA1530、TA1535和TA100。在该方法中，苯乙烯在添加了肝脏线粒体后组分的情况下通常表现出致突变活性。但其致突变活性仍然较弱。此外，在试验过程中似乎通过代谢形成了一种挥发性致突变中间体；其身份尚不清楚。
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