Lundholm C E
Department of Pharmacology, Faculty of Health Sciences, University of Linköping, Sweden.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1994 Sep;109(1):57-62.
Eggshell thinning in ducks was induced by administration of p,p'-DDE in the diet (40 mg/kg food) for 45 days. This treatment resulted in a 19% reduction of the Eggshell Index (EI). Shells from calcifying eggs obtained at the time of slaughter showed a 36% reduction of EI. Prostaglandin synthesis by a homogenate of eggshell gland mucosa from p,p'-DDE-treated ducks was reduced by 24%. HCO3(-)-stimulated ATPase activity by a homogenate of eggshell gland mucosa from p,p'-DDE-treated ducks was not significantly changed. The calcium content of eggshell gland mucosa was increased to 127% in p,p'-DDE-treated ducks. p,p'-DDE-treated ducks showed profound changes in the shell gland luminal content of several ions. Calcium (-43%), sodium (-15%), potassium (-15%), bicarbonate (-33%) and chloride (-29%) were all significantly reduced in p,p'-DDE-treated ducks. The content of phosphate was unchanged. These findings are discussed in relation to a proposed mechanism for p,p'-DDE-induced eggshell thinning that involves inhibition of prostaglandin synthesis in eggshell gland mucosa.
通过在饲料中添加对，对'-滴滴伊（40毫克/千克食物）持续45天，诱导鸭子出现蛋壳变薄的情况。这种处理导致蛋壳指数（EI）降低了19%。屠宰时获取的正在钙化的蛋的蛋壳，其EI降低了36%。来自经对，对'-滴滴伊处理的鸭子的蛋壳腺黏膜匀浆的前列腺素合成减少了24%。经对，对'-滴滴伊处理的鸭子的蛋壳腺黏膜匀浆中，碳酸氢根刺激的ATP酶活性没有显著变化。在经对，对'-滴滴伊处理的鸭子中，蛋壳腺黏膜的钙含量增加到了127%。经对，对'-滴滴伊处理的鸭子在蛋壳腺管腔内容物中的几种离子方面表现出深刻变化。在经对，对'-滴滴伊处理的鸭子中，钙（-43%）、钠（-15%）、钾（-15%）、碳酸氢根（-33%）和氯（-29%）均显著减少。磷酸盐含量未变。结合一种关于对，对'-滴滴伊诱导蛋壳变薄的机制假说对这些发现进行了讨论，该假说涉及抑制蛋壳腺黏膜中的前列腺素合成。
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