Lin W C
Department of Pharmacology, China Medical College, Taichung, Taiwan.
Res Commun Mol Pathol Pharmacol. 1994 Nov;86(2):235-44.
The present study investigated the mechanisms of gastric antisecretory action of pentylenetetrazol (PTZ) in pylorus-ligated rats. Pretreatment with indomethacin, phentolamine, propranolol, 6-hydroxydopamine, flunarizine and nifedipine, which were reported to antagonize seizures induced by PTZ, did not influence the gastric antisecretory action of PTZ. In contrast, pentobarbital and phenobarbital reverse the action of PTZ. These results suggest that prostaglandins production, adrenoceptors and calcium entry are not involved in the gastric antisecretory action of PTZ, and that the GABAA receptor complex plays an important role in the action induced by PTZ.
本研究探讨了戊四氮（PTZ）对幽门结扎大鼠胃分泌的抑制作用机制。据报道，吲哚美辛、酚妥拉明、普萘洛尔、6-羟基多巴胺、氟桂利嗪和硝苯地平可拮抗PTZ诱导的癫痫发作，预先给予这些药物并不影响PTZ的胃分泌抑制作用。相反，戊巴比妥和苯巴比妥可逆转PTZ的作用。这些结果表明，前列腺素生成、肾上腺素能受体和钙内流不参与PTZ的胃分泌抑制作用，且GABAA受体复合物在PTZ诱导的作用中起重要作用。
