Cuturi M C, Blancho G, Josien R, Soulillou J P
INSERM Unité 211, Nantes, France.
Curr Opin Nephrol Hypertens. 1994 Nov;3(6):578-84. doi: 10.1097/00041552-199411000-00003.
Organ transplantation is the treatment of choice for patients with several end-stage renal diseases. Despite improvements in immunosuppression and posttransplantation management of patients, allograft rejection remains a problem. In this review, we focus on the recent advances in molecular biology that have provided new opportunities to explore questions regarding the mechanisms of allograft rejection. We have concentrated on antigen presentation and the role of the direct and indirect pathway in allorecognition; effector mechanisms; adhesion molecules and lymphocyte homing; and the role of cytokines in regulating the different steps of rejection.
器官移植是多种终末期肾病患者的首选治疗方法。尽管患者的免疫抑制和移植后管理有所改善，但同种异体移植排斥仍然是一个问题。在本综述中，我们重点关注分子生物学的最新进展，这些进展为探索同种异体移植排斥机制的相关问题提供了新机会。我们集中讨论了抗原呈递以及直接和间接途径在同种异体识别中的作用；效应机制；黏附分子和淋巴细胞归巢；以及细胞因子在调节排斥反应不同步骤中的作用。
