Solez K, Racusen L C, Abdulkareem F, Kemeny E, von Willebrand E, Truong L D
Department of Pathology, Methodist Hospital, Houston, Texas, USA.
Kidney Int. 1997 May;51(5):1476-80. doi: 10.1038/ki.1997.202.
Despite an increasing amount of immunohistochemical and molecular biology data relating to the pathogenesis of kidney transplant rejection, the pathological diagnosis of this condition still rests on routine light microscopy. The detection of changes in expression and distribution of adhesion molecules in renal allograft biopsies may open a new era of increased accuracy of rejection diagnosis. Of the various adhesion molecule reactivities, peritubular capillary VCAM-1 staining appears to be the most specific finding for chronic rejection. This same staining reaction is seen in acute rejection, but may have less specificity in that setting.
尽管与肾移植排斥反应发病机制相关的免疫组织化学和分子生物学数据越来越多，但这种疾病的病理诊断仍依赖于常规光学显微镜检查。检测肾移植活检中黏附分子表达和分布的变化可能会开启排斥反应诊断准确性提高的新时代。在各种黏附分子反应中，肾小管周围毛细血管VCAM - 1染色似乎是慢性排斥反应最具特异性的表现。在急性排斥反应中也可见相同的染色反应，但在那种情况下特异性可能较低。
