Bianchi M, Panerai A E
Department of Pharmacology, School of Medicine, University of Milano, Italy.
Brain Res Bull. 1995;36(1):113-7. doi: 10.1016/0361-9230(94)00174-y.
After intracerebroventricular administration, both interleukin-1 alpha and corticotropin-releasing hormone increase nociceptive thresholds evaluated by the hot-plate test in the rat. Pretreatment with 6-hydroxydopamine or prazosin fully prevents the action of both substances. Moreover, the effect of interleukin-1 alpha is completely blocked by the intracerebroventricular administration of the corticotropin-releasing hormone antagonist alpha-helical CRH 9-41. Our results suggest an involvement of CRH and the noradrenergic system in the antinociceptive effect of central interleukin-1 alpha.
脑室内给药后，白细胞介素-1α和促肾上腺皮质激素释放激素均可提高通过大鼠热板试验评估的痛觉阈值。用6-羟基多巴胺或哌唑嗪预处理可完全阻断这两种物质的作用。此外，脑室内注射促肾上腺皮质激素释放激素拮抗剂α-螺旋CRH 9-41可完全阻断白细胞介素-1α的作用。我们的结果表明，促肾上腺皮质激素释放激素和去甲肾上腺素能系统参与了中枢白细胞介素-1α的镇痛作用。
