脑室内注射白细胞介素-1β对大鼠机械性伤害感受的双相作用。
Biphasic effects of intracerebroventricular interleukin-1 beta on mechanical nociception in the rat.
作者信息
Yabuuchi K, Nishiyori A, Minami M, Satoh M
机构信息
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
出版信息
Eur J Pharmacol. 1996 Apr 4;300(1-2):59-65. doi: 10.1016/0014-2999(95)00862-4.
The effects of interleukin-1 beta on the mechanical nociceptive threshold in rat were examined using the paw-pressure test. An intracerebroventricular (i.c.v.) injection of interleukin-1 beta at doses of 10 and 100 pg/rat caused hyperalgesia to mechanical stimuli. Higher doses of interleukin-1 beta (1 and 10 ng/rat) induced an analgesic effect. The coadministration of the interleukin-1 receptor antagonist completely antagonized the hyperalgesic and analgesic effects of interleukin-1 beta. An i.c.v. injection of alpha-helical-corticotropin-releasing factor [9-41] 15 min prior to interleukin-1 beta administration completely blocked the hyperalgesic and analgesic effects of interleukin-1 beta. An i.c.v. injection of sodium salicylate 15 min prior to interleukin-1 beta administration inhibited the hyperalgesic effect of interleukin-1 beta, but not the analgesic effect. These results suggest that interleukin-1 beta produces biphasic effects on the mechanical nociceptive threshold through the interleukin-1 receptor in the brain and that a corticotropin-releasing factor-mediated pathway is involved. Furthermore, the hyperalgesic effect of interleukin-1 beta may be mediated by prostaglandins.
采用 paw - 压力试验检测白细胞介素 - 1β 对大鼠机械性伤害感受阈值的影响。脑室内（i.c.v.）注射剂量为 10 和 100 pg/大鼠的白细胞介素 - 1β 会导致对机械刺激的痛觉过敏。更高剂量的白细胞介素 - 1β（1 和 10 ng/大鼠）诱导产生镇痛作用。白细胞介素 - 1 受体拮抗剂的共同给药完全拮抗了白细胞介素 - 1β 的痛觉过敏和镇痛作用。在给予白细胞介素 - 1β 前 15 分钟脑室内注射 α - 螺旋促肾上腺皮质激素释放因子 [9 - 41] 完全阻断了白细胞介素 - 1β 的痛觉过敏和镇痛作用。在给予白细胞介素 - 1β 前 15 分钟脑室内注射水杨酸钠抑制了白细胞介素 - 1β 的痛觉过敏作用，但未抑制其镇痛作用。这些结果表明，白细胞介素 - 1β 通过脑中的白细胞介素 - 1 受体对机械性伤害感受阈值产生双相作用，并且涉及促肾上腺皮质激素释放因子介导的途径。此外，白细胞介素 - 1β 的痛觉过敏作用可能由前列腺素介导。
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