Kitano H, Takeda T, Pulec J L, Saadat D, Uchida K
Department of Otolaryngology, Head and Neck Surgery, Shiga University of Medical Science, Japan.
Ear Nose Throat J. 1994 Dec;73(12):921-5.
Clinical studies have shown that plasma vasopressin level is significantly elevated in patients with Meniere's disease. Other reports indicated that histamine induced a very quick and high elevation of vasopressin level and caused nystagmus in experimentally produced endolymphatic hydrops. We became interested in further investigating the details of this relationship by studying the effect of experimental endolymphatic hydrops and histamine upon plasma vasopressin level in the guinea pig. The results are as follows: 1) Histamine increased the plasma vasopressin level in normal guinea pigs. 2) There was no statistically significant difference in the plasma vasopressin level between the hydrops model and normal guinea pigs. 3) Histamine increased the plasma vasopressin level more in the hydrops model group than in normals. 4) Plasma vasopressin level was elevated in the vertiginous model caused by inner ear anesthesia. Our results support those of clinical investigators who reported that the plasma vasopressin level was elevated more in the Meniere's disease group than any other equilibrium disorder group. It is possible that vasopressin is in someway involved in the development of endolymphatic hydrops.
临床研究表明，梅尼埃病患者的血浆血管加压素水平显著升高。其他报告指出，组胺可使血管加压素水平迅速大幅升高，并在实验性内淋巴积水模型中引发眼球震颤。我们通过研究实验性内淋巴积水和组胺对豚鼠血浆血管加压素水平的影响，对这一关系的细节进行了深入研究。结果如下：1）组胺可使正常豚鼠的血浆血管加压素水平升高。2）积水模型组与正常豚鼠的血浆血管加压素水平无统计学显著差异。3）组胺使积水模型组的血浆血管加压素水平升高幅度大于正常组。4）内耳麻醉所致的眩晕模型中血浆血管加压素水平升高。我们的研究结果支持临床研究人员的结论，他们报告称梅尼埃病组的血浆血管加压素水平升高幅度高于其他任何平衡障碍组。血管加压素可能在某种程度上参与了内淋巴积水的发生发展。
