来自环节动物蚯蚓的一种细胞质中间丝（IF）蛋白序列突出了原口动物IF蛋白的一个显著特征。
The sequence of a cytoplasmic intermediate filament (IF) protein from the annelid Lumbricus terrestris emphasizes a distinctive feature of protostomic IF proteins.
作者信息
Bovenschulte M, Riemer D, Weber K
机构信息
Max Planck Institute for Biophysical Chemistry, Department of Biochemistry, Goettigen, Germany.
出版信息
FEBS Lett. 1995 Mar 6;360(3):223-6. doi: 10.1016/0014-5793(95)00108-l.
The complete cDNA clone for a cytoplasmic intermediate filament (IF) protein from the annelid Lumbricus terrestris reported here, shows an extra 42 residues in the coil 1b subdomain of the central rod, as do the IF proteins from nematodes and molluscs. These extra six heptads are also present in all nuclear lamins but not in any known vertebrate cytoplasmic IF protein. Thus, it seems that protostomic metazoa conserve a lamin-like structural element in their cytoplasmic IF proteins, which was lost in the deuterostomic metazoan branch leading to the vertebrates.
本文报道的来自环节动物蚯蚓的一种细胞质中间丝（IF）蛋白的完整cDNA克隆显示，其中心杆的卷曲1b亚结构域中有额外的42个残基，线虫和软体动物的IF蛋白也是如此。这额外的六个七肽在所有核纤层蛋白中也存在，但在任何已知的脊椎动物细胞质IF蛋白中都不存在。因此，似乎原口后生动物在其细胞质IF蛋白中保留了一种类似核纤层蛋白的结构元件，而在导致脊椎动物的后口后生动物分支中则丢失了这种元件。
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