Sehgal S, Bhattacharya D, Bhardwaj M, Parsi V
Zoonosis Division, NICD, Delhi.
Indian J Public Health. 1994 Jan-Mar;38(1):18-21.
Ninety persons were bitten by a single rabid dog on 23rd January, 1992 in Central Delhi area. All patients were given immediate first-aid, prophylactic tetanus toxoid injection and post-exposure antirabies treatment i.e., hyperimmune antirabies serum (ARS) and antirabies vaccination in different Hospitals of Delhi. Fifteen (15) patients received tissue culture antirabies vaccine (Rabipur or Verorab) and rest 75 patients were given nervous tissue vaccine. ARS was given to all patients as all had severe (Class-III) bite. Altogether there were 76 male and 14 female and 80 adult and 10 children bitten by the dog. All patients well tolerated the vaccines excepting a few, who developed very minor side-effects. Investigation regarding post-exposure antirabies antibody assessment were carried out in twenty-four patients at WHO Collaborative Centre for Rabies. Epidemiology for South-east Asia at National Institute of Communicable Diseases, Delhi. Paired blood samples were obtained from these patients and all of them had protective antibody titre (0.5 IU/ml) with mean titre of 1.81 IU/ml and 2.11 IU/ml in first and second samples, respectively. All patients were followed after six months and there were no death or vaccine failure reported.
1992年1月23日，在德里市中心地区，90人被一只狂犬咬伤。所有患者均在德里的不同医院接受了立即急救、预防性破伤风类毒素注射以及暴露后抗狂犬病治疗，即高效价抗狂犬病血清（ARS）和抗狂犬病疫苗。15名患者接种了组织培养抗狂犬病疫苗（Rabipur或Verorab），其余75名患者接种了神经组织疫苗。由于所有患者均为严重（III级）咬伤，因此均接受了ARS治疗。共有76名男性和14名女性被狗咬伤，其中80名是成年人，10名是儿童。除少数出现非常轻微的副作用外，所有患者对疫苗耐受性良好。在德里国家传染病研究所的世界卫生组织狂犬病东南亚合作中心，对24名患者进行了暴露后抗狂犬病抗体评估调查。从这些患者身上采集了配对血样，所有患者均具有保护性抗体滴度（0.5 IU/ml），第一份和第二份样本的平均滴度分别为1.81 IU/ml和2.11 IU/ml。所有患者在六个月后接受随访，未报告死亡或疫苗接种失败情况。
