Sehgal S, Bhardwaj M, Bhattacharya D
WHO Collaborative Centre for Rabies Epidemiology for South-East Asia Zoonosis Division, National Institute of Communicable Diseases (NICD), Sham Nath Marg, Delhi.
Indian Pediatr. 1994 Feb;31(2):133-7.
Two hundred seventy-one children reported at the WHO Collaborative Centre for Rabies Epidemiology for South-East Asia at National Institute of Communicable Diseases, Delhi, for advice and antirabies antibody assessment after post-exposure prophylaxis with purified chick embryo cell (PCEC) antirabies vaccine from January 1986 to October 1992. Vaccine was very well tolerated by these children and only 7% complained about mild to moderate side reactions like pain, induration, fever or rash. On an average, every year 50-55 children had reported at this Centre after post-exposure vaccination with PCEC vaccine excepting years 1986 and 1987. One hundred and forty-four children underwent complete course of post-exposure prophylaxis, i.e., 5 or 6 doses on day 0, 3, 7, 14, 30 and 90 (optional) of PCEC vaccine were administered, forty-three (43) children received 4 doses on day 0, 7, 14 and 30 (day 3 dose was omitted) and eighty-four (84) children received 2 to 3 doses as the biting animals were alive for 10 days in these cases. Two hundred and twenty-nine children (84.5%) were bitten by dogs and in 10%, the dog was proven rabid by laboratory examination of dog brain. One hundred and forty-nine (55%) had Class III bite. Serological response, i.e., antirabies antibody titre in all these children were satisfactory (> 0.5 IU/ml) with mean titre of 1.98 IU/ml irrespective of doses of PCEC vaccine administered. No vaccine failure was observed in this study.
1986年1月至1992年10月期间，271名儿童前往位于德里的国家传染病研究所的世界卫生组织东南亚狂犬病流行病学合作中心，寻求建议并接受暴露后预防接种精制鸡胚细胞（PCEC）狂犬病疫苗后的抗狂犬病抗体评估。这些儿童对疫苗的耐受性非常好，只有7%的儿童抱怨有轻度至中度的副作用，如疼痛、硬结、发热或皮疹。除了1986年和1987年，平均每年有50 - 55名儿童在该中心接种PCEC疫苗后前来报告。144名儿童接受了完整的暴露后预防疗程，即在第0、3、7、14、30和90天（可选）接种5或6剂PCEC疫苗；43名儿童在第0、7、14和30天接种了4剂（省略了第3天的剂量）；84名儿童因咬人的动物存活了10天而接种了2至3剂。229名儿童（84.5%）被狗咬伤，其中10%的狗经狗脑实验室检查证实患有狂犬病。149名（55%）为III级咬伤。所有这些儿童的血清学反应，即抗狂犬病抗体滴度均令人满意（> 0.5 IU/ml），无论接种的PCEC疫苗剂量如何，平均滴度为1.98 IU/ml。本研究中未观察到疫苗接种失败的情况。
