Deorari A K, Singh M, Ahuja G K, Bisht M S, Verma A, Paul V K, Tandon D A
Department of Pediatrics, Neurology and Otorhinolaryngology, All India Institute of Medical Science, Ansari Nagar, New Delhi.
Indian Pediatr. 1994 Aug;31(8):915-21.
Brainstem auditory evoked responses (BAER) were longitudinally recorded prospectively in 18 term infants with neonatal hyperbilirubinemia (NHB) (total serum bilirubin > 15 mg/dl). Seven neonates had abnormal BAER. Wave complex IV-V was absent in eight recordings in NHB group while they were normal in the control group (p < 0.001). Prolongation of latency of waves I and V and interwave conduction time (wave I-V) occurred in jaundiced infants especially when unconjugated serum bilirubin level rose above 22 mg/dl. The abnormalities in BAER reversed to normal in all seven neonates after exchange blood transfusion indicating transient nature of bilirubin toxicity to the brain. All seven neonates in the study and control group had normal hearing, development quotient and were free of neurological sequelae on follow up for one year.
对18名足月新生儿高胆红素血症（NHB）（总血清胆红素>15mg/dl）患儿进行前瞻性纵向脑干听觉诱发电位（BAER）记录。7名新生儿BAER异常。NHB组8次记录中IV-V波复合波缺失，而对照组正常（p<0.001）。黄疸婴儿出现I波和V波潜伏期及I-V波间期延长，尤其是当血清未结合胆红素水平升至22mg/dl以上时。7名新生儿换血治疗后BAER异常均恢复正常，提示胆红素对脑的毒性具有短暂性。研究组和对照组的所有7名新生儿听力、发育商均正常，随访1年无神经后遗症。
