毒鹅膏菌中毒的诊断与治疗：硫辛酸的应用
Diagnosis and treatment of Amanita phalloides-type mushroom poisoning: use of thioctic acid.
作者信息
Becker C E, Tong T G, Boerner U, Roe R L, ScoTT A T, MacQuarrie M B, Bartter F
出版信息
West J Med. 1976 Aug;125(2):100-9.
Abstract
The number of cases of mushroom poisoning is increasing as a result of the increasing popularity of "wild" mushroom consumption. Amanitin and phalloidin cytotoxins found in some Amanita and Galerina species produce the most severe and frequent life-threatening symptoms of Amanita phalloidestype poisoning. Delay in onset of symptoms, individual susceptibility variation and lack of rapid and reliable identification have contributed to the significant morbidity and mortality of this type of poisoning.A rapid chromatographic assay for identifying the potent cytotoxins and apparently successful management using thioctic acid of two cases of A. phalloides-type mushroom poisoning are reported. All known cases of A. phalloides-type mushroom poisoning treated with thioctic acid in the United States are summarized.
摘要
由于“野生”蘑菇消费日益流行，蘑菇中毒病例数量正在增加。在一些鹅膏菌属和盔孢伞属物种中发现的鹅膏毒肽和鬼笔环肽细胞毒素会产生最严重且最常见的危及生命的毒鹅膏中毒症状。症状出现延迟、个体易感性差异以及缺乏快速可靠的鉴定方法，导致了这类中毒的高发病率和高死亡率。本文报道了一种用于鉴定强效细胞毒素的快速色谱分析方法，以及使用硫辛酸对两例毒鹅膏型蘑菇中毒进行的明显成功的治疗。总结了美国所有已知用硫辛酸治疗的毒鹅膏型蘑菇中毒病例。
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