Lundin K E, Scott H, Fausa O, Thorsby E, Sollid L M
Institute of Transplantation Immunology, National Hospital, Oslo, Norway.
Hum Immunol. 1994 Dec;41(4):285-91. doi: 10.1016/0198-8859(94)90047-7.
CD is an immunologic disease of the small intestine which is precipitated by ingestion of wheat gliadin. Most patients carry the HLA-DQ (alpha 10501, beta 10201) (DQ2) heterodimer. We recently reported that a preponderance of gliadin-specific T cells from the small intestinal mucosa of DQ2-positive CD patients were restricted by this DQ heterodimer. However, a small percentage of CD patients do not carry this DQ heterodimer, and most of them instead carry DQ (alpha 10301, beta 10302) (DQ8). Here we report that a majority of gliadin-specific T cells from the small intestinal mucosa of a DR4,DQ7/DR4,DQ8 heterozygous CD patient are restricted by DQ8. Thus, preferential presentation of gliadin-derived peptides to T cells by the CD-associated DQ2 and DQ8 molecules may be an initial and important immunopathogenic step in CD.
乳糜泻是一种小肠免疫性疾病，由摄入小麦醇溶蛋白引发。大多数患者携带HLA-DQ（α10501，β10201）（DQ2）异二聚体。我们最近报道，来自DQ2阳性乳糜泻患者小肠黏膜的醇溶蛋白特异性T细胞大多受此DQ异二聚体限制。然而，一小部分乳糜泻患者不携带这种DQ异二聚体，其中大多数携带DQ（α10301，β10302）（DQ8）。在此我们报道，一名DR4、DQ7/DR4、DQ8杂合乳糜泻患者小肠黏膜的大多数醇溶蛋白特异性T细胞受DQ8限制。因此，与乳糜泻相关的DQ2和DQ8分子将醇溶蛋白衍生肽优先呈递给T细胞可能是乳糜泻初始且重要的免疫致病步骤。
