Akingbemi B T, Aire T A
Department of Preclinical Veterinary Studies, University of Zimbabwe, Harare.
J Comp Pathol. 1994 Nov;111(4):413-26. doi: 10.1016/s0021-9975(05)80099-4.
The effects of protein malnutrition on haematological and serum biochemical values were evaluated in gossypol-treated rats which were simultaneously fed with ethanol. Gossypol caused anaemia, leucopenia and thrombocytopenia in malnourished animals, suggesting a depression of bone marrow activity. Gossypol also caused a significant elevation of serum alkaline phosphatase and alanine aminotransferase activities and increases in the concentrations of Mg++ and Ca++ with reduced albumin, regardless of the nutritional status. These changes were more severe with malnutrition. Ethanol alone caused a thrombocytopenia but no other significant haematological changes. However, it appeared to cause derangement of lipid and protein metabolism as reflected in serum cholesterol and urea. The toxic effects seen in gossypol-treated rats were significantly reduced in animals simultaneously given ethanol. As the livers of gossypol-treated rats were significantly heavier than in these animals, it seems possible that ethanol consumption enhances the ability of the liver to metabolize gossypol, thereby reducing its accumulation and consequently its toxicity. However, further studies are needed to determine the mechanisms responsible.
在同时给予乙醇的棉酚处理大鼠中，评估了蛋白质营养不良对血液学和血清生化指标的影响。棉酚导致营养不良动物出现贫血、白细胞减少和血小板减少，提示骨髓活性受到抑制。无论营养状况如何，棉酚还导致血清碱性磷酸酶和丙氨酸转氨酶活性显著升高，镁离子和钙离子浓度增加，白蛋白减少。营养不良时这些变化更为严重。单独给予乙醇会导致血小板减少，但无其他显著的血液学变化。然而，它似乎导致了血清胆固醇和尿素所反映的脂质和蛋白质代谢紊乱。在同时给予乙醇的动物中，棉酚处理大鼠所见的毒性作用显著降低。由于棉酚处理大鼠的肝脏明显比这些动物的肝脏重，乙醇摄入似乎有可能增强肝脏代谢棉酚的能力，从而减少其蓄积并因此降低其毒性。然而，需要进一步研究以确定其作用机制。
