Akingbemi B T, Ogwuegbu S O, Onwuka S K, Oke B O, Aire T A
Department of Veterinary Anatomy, University of Ibadan, Nigeria.
J Comp Pathol. 1995 May;112(4):361-71. doi: 10.1016/s0021-9975(05)80017-9.
This study was designed to evaluate the interaction between protein malnutrition, gossypol treatment and blood parasitosis (Trypanosoma brucei) in the Wistar rat. Haematological and serum biochemical changes were evaluated in the rats, which were placed on two planes of nutrition--low protein (LP) and normal protein (NP)--and either treated with gossypol or infected with Trypanosoma brucei, or both. Higher parasitaemia occurred in gossypol-treated NP rats than in the corresponding LP group. Gossypol treatment and trypanosomal infection, either alone or in concert, caused an anaemia that was both macrocytic and hypochromic. Both treatments together also caused increases in serum alkaline phosphatase and alanine aminotransferase activities, which were accompanied by depressed serum albumin concentrations, suggestive of hepatic dysfunction in affected rats. These results suggest that, with adequate protein intake, the growth and infectivity of trypanosomes is not inhibited by gossypol but that protein malnutrition has a beneficial effect of reduced parasitaemia. Unfortunately, this beneficial effect is counteracted by gossypol enhancement of hepatic dysfunction caused by trypanosomes.
本研究旨在评估蛋白质营养不良、棉酚治疗与Wistar大鼠血液寄生虫病（布氏锥虫）之间的相互作用。对处于两种营养水平——低蛋白（LP）和正常蛋白（NP）——且要么接受棉酚治疗、要么感染布氏锥虫、要么二者皆有的大鼠的血液学和血清生化变化进行了评估。接受棉酚治疗的NP组大鼠的寄生虫血症高于相应的LP组。棉酚治疗和锥虫感染单独或共同作用均导致了大细胞低色素性贫血。两种治疗共同作用还导致血清碱性磷酸酶和丙氨酸转氨酶活性升高，同时伴有血清白蛋白浓度降低，提示受影响大鼠存在肝功能障碍。这些结果表明，在蛋白质摄入充足的情况下，锥虫的生长和感染性不受棉酚抑制，但蛋白质营养不良具有降低寄生虫血症的有益作用。不幸的是，这种有益作用被棉酚增强锥虫引起的肝功能障碍所抵消。
