Viinikka L, Ylikorkala O, Nummi S, Virkkunen P, Ranta T, Alapiessa U, Vihko R
Acta Endocrinol (Copenh). 1976 Oct;83(2):429-38. doi: 10.1530/acta.0.0830429.
The biological effects of a new synthetic progestagen, Org 2969 (13-ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol) were studied in healthy normally menstruating women. Two of them were given 0.125 mg, five 0.060 mg and two 0.030 mg of Org 2969 daily on days 1-20 during one menstrual cycle. Serum levels of follicle stimulating hormone, luteinizing hormone, progesterone and oestradiol were analyzed on days 8-23 in order to evaluate the function of the hypophyseal-ovarian axis. The serum concentrations of aspartate amino transferase, alanine amino transferase, alkaline phosphatase, gamma glutamyl transpeptidase and bilirubin were determined to evaluate possible side effects on live function on days 8, 15 and 23. Serum cortisol was measured on days 8 and 23. The basal body temperature was recorded daily during the whole cycle, and endometrium biopsies were taken on days 21 or 22 of the cycle. All samples were taken similaryl during the treatment cycle and the preceding control cycle. According to the hormone determinations, all the treatment cycles were anovulatory except in one woman receiving the lowest dose. The treatment led to decreased spinnbarkeit, arborization and sperum penetration in the cervical mucus. Liver function tests and serum cortisol remained unchanged during the treatment.
在健康的正常月经周期女性中研究了一种新型合成孕激素Org 2969（13-乙基-11-亚甲基-18,19-二去甲-17α-孕-4-烯-20-炔-17-醇）的生物学效应。在一个月经周期的第1至20天，其中两名女性每天服用0.125毫克Org 2969，五名女性每天服用0.060毫克，两名女性每天服用0.030毫克。在第8至23天分析血清促卵泡激素、促黄体生成素、孕酮和雌二醇水平，以评估垂体-卵巢轴的功能。在第8、15和23天测定血清天冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶、γ-谷氨酰转肽酶和胆红素的浓度，以评估对肝功能可能产生的副作用。在第8和23天测量血清皮质醇。在整个周期中每天记录基础体温，并在周期的第21或22天进行子宫内膜活检。在治疗周期和之前的对照周期中，所有样本的采集方式相似。根据激素测定结果，除一名接受最低剂量的女性外，所有治疗周期均无排卵。治疗导致宫颈黏液的拉丝度、分支化和精子穿透能力下降。治疗期间肝功能检查和血清皮质醇保持不变。
