口服耐受与免疫治疗机制综述。
A review of the mechanisms of oral tolerance and immunotherapy.
作者信息
Sosroseno W
机构信息
Department of Dental Public Health, Faculty of Dentistry, Gadjah Mada University, Yogyakarta, Indonesia.
出版信息
J R Soc Med. 1995 Jan;88(1):14-7.
The induction of oral tolerance by oral immunization has been well recognized. Accumulated evidence shows that oral tolerance can be mediated by orally activated humoral and cellular factors. In animal models, the development of several T cell-mediated autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, uveitis and diabetes type 1 can be inhibited by oral immunization of the respective antigens. In allergy, oral administration of certain allergens can prevent and reduce both contact and atopic dermatitis. Oral tolerance to alloantigen also reduces graft rejection. In spite of these encouraging results, the usefulness of this approach for an alternative immunotherapy in humans needs to be investigated further.
口服免疫诱导口服耐受已得到充分认可。越来越多的证据表明，口服耐受可由口服激活的体液和细胞因子介导。在动物模型中，口服相应抗原可抑制多种T细胞介导的自身免疫性疾病的发展，如多发性硬化症、类风湿性关节炎、葡萄膜炎和1型糖尿病。在过敏方面，口服某些变应原可预防和减轻接触性皮炎和特应性皮炎。对同种异体抗原的口服耐受也可减少移植排斥反应。尽管有这些令人鼓舞的结果，但这种方法在人类替代免疫治疗中的实用性仍需进一步研究。
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