微环境免疫调节：抗抑制细胞在维持肠道相关淋巴组织免疫反应中的可能作用。

Microenvironmental immunoregulation: possible role of contrasuppressor cells in maintaining immune responses in gut-associated lymphoid tissues.

作者信息

Green D R, Gold J, St Martin S, Gershon R, Gershon R K

出版信息

Proc Natl Acad Sci U S A. 1982 Feb;79(3):889-92. doi: 10.1073/pnas.79.3.889.

DOI:10.1073/pnas.79.3.889

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC345858/

Abstract

The addition of Peyer's patch T cells from most strains of mice to spleen cells in primary Mishell-Dutton cultures either has no effect or augments the spleen cells' response to sheep erythrocytes. However, if the Peyer's patch T cells are treated with an anti-I-J antiserum and complement to remove contrasuppressor-inducer cells, the remaining Ly-2 cells (T cells that express Ly-2 but not Ly-1) are highly suppressive. This "latent" suppressor cell activity also can be revealed by removing contrasuppressor-acceptor (transducer) cells from the splenic assay population with either an anti-I-J or anti-Ly-2 antiserum. These findings, taken together with previous work showing that orally administered antigen leads to systemic tolerance, give experimental support to the notion that contrasuppression may be important in allowing microenvironmental immune responses (in this case the gut-associated lymphoid tissue) to take place while systemic immunity is suppressed.

摘要

在初次米舍尔-达顿培养中，将大多数品系小鼠的派尔集合淋巴结T细胞添加到脾细胞中，要么没有效果，要么增强脾细胞对绵羊红细胞的反应。然而，如果用抗I-J抗血清和补体处理派尔集合淋巴结T细胞以去除抗抑制诱导细胞，剩余的Ly-2细胞（表达Ly-2但不表达Ly-1的T细胞）具有高度抑制性。通过用抗I-J或抗Ly-2抗血清从脾检测群体中去除抗抑制受体（转导细胞），也可以揭示这种“潜在”的抑制细胞活性。这些发现，连同先前表明口服抗原导致全身耐受的研究工作，为抗抑制在全身免疫受到抑制时允许微环境免疫反应（在这种情况下是肠道相关淋巴组织）发生中可能起重要作用的观点提供了实验支持。

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Microenvironmental immunoregulation: possible role of contrasuppressor cells in maintaining immune responses in gut-associated lymphoid tissues.微环境免疫调节：抗抑制细胞在维持肠道相关淋巴组织免疫反应中的可能作用。

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本文引用的文献

1

Systemic tolerance and secretory immunity after oral immunization.口服免疫后的全身耐受性和分泌性免疫

J Exp Med. 1980 Dec 1;152(6):1459-72. doi: 10.1084/jem.152.6.1459.

2

Studies of the cell surface of mouse dendritic cells and other leukocytes.小鼠树突状细胞和其他白细胞细胞表面的研究。

J Exp Med. 1981 Jul 1;154(1):168-87. doi: 10.1084/jem.154.1.168.

3

Immunoregulatory circuits that modulate responsiveness to suppressor cell signal. Failure of B10 mice to respond to suppressor factors can be overcome by quenching the contrasuppressor circuit.调节对抑制性细胞信号反应性的免疫调节回路。通过消除反抑制回路可克服B10小鼠对抑制因子无反应的情况。

J Exp Med. 1981 Jun 1;153(6):1547-61. doi: 10.1084/jem.153.6.1547.

4

Contrasuppression. A novel immunoregulatory activity.反向抑制。一种新型免疫调节活性。

J Exp Med. 1981 Jun 1;153(6):1533-46. doi: 10.1084/jem.153.6.1533.

5

Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。

Immunology. 1968 Apr;14(4):599-600.

6

A mechanism for the induction of immunological tolerance by antigen feeding: antigen-antibody complexes.通过抗原喂食诱导免疫耐受的机制：抗原-抗体复合物

J Exp Med. 1975 Dec 1;142(6):1509-19. doi: 10.1084/jem.142.6.1509.

7

Immunologic suppression after oral administration of antigen. I. Specific suppressor cells formed in rat Peyer's patches after oral administration of sheep erythrocytes and their systemic migration.口服抗原后的免疫抑制。I. 口服绵羊红细胞后大鼠派伊尔结中形成的特异性抑制细胞及其全身迁移。

J Immunol. 1978 Nov;121(5):1878-83.

8

"Panning" for lymphocytes: a method for cell selection.“淘选”淋巴细胞：一种细胞选择方法。

Proc Natl Acad Sci U S A. 1978 Jun;75(6):2844-8. doi: 10.1073/pnas.75.6.2844.

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