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1
Two distinct antigen-specific suppressor factors induced by the oral administration of antigen.经口服抗原诱导产生的两种不同的抗原特异性抑制因子。
J Exp Med. 1980 Sep 1;152(3):545-54. doi: 10.1084/jem.152.3.545.
2
Investigations into the nature of Igh-V region-restricted T cell interactions by using antibodies to antigens on methylcholanthrene-induced sarcomas. I. Analysis of an Igh-V-restricted suppressor-inducer factor.利用针对甲基胆蒽诱导肉瘤上抗原的抗体对Igh-V区限制性T细胞相互作用的性质进行研究。I. Igh-V限制性抑制诱导因子的分析。
J Immunol. 1985 Mar;134(3):1665-72.
3
Mechanisms of Ly2 suppressor cell activity. Activation of an Ly1 I-J+ cell is required to transduce the suppressive signal.Ly2抑制性细胞活性的机制。转导抑制信号需要激活Ly1 I-J+细胞。
J Exp Med. 1984 May 1;159(5):1413-28. doi: 10.1084/jem.159.5.1413.
4
Immunoregulatory circuits that modulate responsiveness to suppressor cell signal. Failure of B10 mice to respond to suppressor factors can be overcome by quenching the contrasuppressor circuit.调节对抑制性细胞信号反应性的免疫调节回路。通过消除反抑制回路可克服B10小鼠对抑制因子无反应的情况。
J Exp Med. 1981 Jun 1;153(6):1547-61. doi: 10.1084/jem.153.6.1547.
5
Regulation of immune responses by T cell subsets. Role of helper and suppressor T cells in the development and expression of MHC-restricted antibody responses to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X responder)F1 spleen cells.T细胞亚群对免疫反应的调节。辅助性T细胞和抑制性T细胞在（应答者×应答者）F1脾细胞对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的MHC限制性抗体反应的发生和表达中的作用。
J Immunol. 1986 Feb 15;136(4):1201-9.
6
Immunosuppression caused by antigen feeding. I. Evidence for the activation of a feedback suppressor pathway in the spleens of antigen-fed mice.抗原喂食引起的免疫抑制。I. 抗原喂食小鼠脾脏中反馈抑制途径激活的证据。
Eur J Immunol. 1982 Sep;12(9):767-73. doi: 10.1002/eji.1830120912.
7
Contrasuppressor cells that break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+), and B cells.破坏口服耐受性的抗抑制细胞是不同于辅助性T细胞（L3T4 +）、抑制性T细胞（Lyt - 2 +）和B细胞的抗原特异性T细胞。
J Immunol. 1987 Nov 15;139(10):3251-9.
8
T cell development in B cell deficient mice. III. Restriction specificity of suppressor T cell factor(s) produced in mice treated chronically with rabbit anti-mouse mu chain antibody.B细胞缺陷小鼠中的T细胞发育。III. 用兔抗小鼠μ链抗体长期处理的小鼠所产生的抑制性T细胞因子的限制特异性。
J Mol Cell Immunol. 1985;2(2):107-17.
9
Modulation of mouse anti-SRBC antibody responses by placental extracts. II. Antigen specificity and regulatory role of B and T cell populations affected by two distinct placental fractions.胎盘提取物对小鼠抗绵羊红细胞抗体反应的调节。II. 两种不同胎盘组分对B细胞和T细胞群体的抗原特异性及调节作用
J Immunol. 1986 Jan;136(2):574-81.
10
Homologies between cell interaction molecules controlled by major histocompatibility complex- and Igh-V-linked genes that T cells use for communication; both molecules undergo "adaptive" differentiation in the thymus.主要组织相容性复合体和免疫球蛋白重链可变区（Igh-V）连锁基因所控制的、T细胞用于通讯的细胞相互作用分子之间的同源性；这两种分子在胸腺中都经历“适应性”分化。
Eur J Immunol. 1983 Apr;13(4):285-91. doi: 10.1002/eji.1830130404.

引用本文的文献

1
Effect of multiple antigenic exposures in the gut on oral tolerance and induction of antibacterial systemic immunity.肠道中多次抗原暴露对口服耐受及抗菌全身免疫诱导的影响。
Infect Immun. 1999 Nov;67(11):5917-24. doi: 10.1128/IAI.67.11.5917-5924.1999.
2
A review of the mechanisms of oral tolerance and immunotherapy.口服耐受与免疫治疗机制综述。
J R Soc Med. 1995 Jan;88(1):14-7.
3
Effect of prior intragastric antigen administration on primary and secondary anti-ovalbumin responses of C57BL/6 and NZB mice.预先胃内给予抗原对C57BL/6和NZB小鼠初次和二次抗卵清蛋白反应的影响。
J Exp Med. 1982 Oct 1;156(4):1256-61. doi: 10.1084/jem.156.4.1256.
4
Lack of oral tolerance in C3H/HeJ mice.C3H/HeJ小鼠中缺乏口服耐受。
J Exp Med. 1982 Feb 1;155(2):605-10. doi: 10.1084/jem.155.2.605.
5
Study of autoimmune response to rat male accessory glands in rats born to immune mothers.对免疫母鼠所生大鼠的雄性附属性腺自身免疫反应的研究。
Immunology. 1984 Sep;53(1):141-5.
6
Immunoregulatory circuits that modulate responsiveness to suppressor cell signal. Failure of B10 mice to respond to suppressor factors can be overcome by quenching the contrasuppressor circuit.调节对抑制性细胞信号反应性的免疫调节回路。通过消除反抑制回路可克服B10小鼠对抑制因子无反应的情况。
J Exp Med. 1981 Jun 1;153(6):1547-61. doi: 10.1084/jem.153.6.1547.
7
Interactions of food antigens, antibodies, and antigen-antibody complexes in health and disease.食物抗原、抗体及抗原-抗体复合物在健康与疾病中的相互作用。
Clin Rev Allergy. 1984 Feb;2(1):69-78. doi: 10.1007/BF02991212.
8
Use of anti-idiotype immunosorbents to isolate circulating antigen-specific T cell-derived molecules from hyperimmune sera.使用抗独特型免疫吸附剂从超免疫血清中分离循环抗原特异性T细胞衍生分子。
Proc Natl Acad Sci U S A. 1983 Mar;80(5):1435-9. doi: 10.1073/pnas.80.5.1435.
9
The use of a monoclonal i-j-specific antibody to distinguish cells in the feedback suppression circuit from those in the contrasuppressor circuit.使用单克隆i-j特异性抗体来区分反馈抑制回路中的细胞与抗抑制回路中的细胞。
Immunogenetics. 1982;16(6):551-8. doi: 10.1007/BF00372023.
10
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.参与抗原特异性人类T细胞功能的克隆型结构。与T3分子复合物的关系。
J Exp Med. 1983 Feb 1;157(2):705-19. doi: 10.1084/jem.157.2.705.

本文引用的文献

1
Cell cooperation during in vivo anti-hapten antibody responses. V. Two synergistic Ly-1+23- helper T cells with distinctive specificities.体内抗半抗原抗体应答过程中的细胞协作。V. 两种具有独特特异性的协同性Ly-1⁺23⁻辅助性T细胞。
Eur J Immunol. 1980 Apr;10(4):231-6. doi: 10.1002/eji.1830100402.
2
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
3
Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
4
The induction of tolerance to a soluble protein antigen by oral administration.通过口服诱导对可溶性蛋白质抗原的耐受性。
Immunology. 1974 Oct;27(4):631-9.
5
A mechanism for the induction of immunological tolerance by antigen feeding: antigen-antibody complexes.通过抗原喂食诱导免疫耐受的机制：抗原-抗体复合物
J Exp Med. 1975 Dec 1;142(6):1509-19. doi: 10.1084/jem.142.6.1509.
6
Properties of primed suppressor T cells and their products.致敏抑制性T细胞及其产物的特性。
Transplant Rev. 1975;26:106-29. doi: 10.1111/j.1600-065x.1975.tb00177.x.
7
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.小鼠抗体应答调节中抗原特异性抑制性T细胞因子的特性。IV. H-2组织相容性复合体内编码抑制性T细胞因子的基因的特殊亚区定位
J Exp Med. 1976 Sep 1;144(3):713-25. doi: 10.1084/jem.144.3.713.
8
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. III. Dual gene control of the T-cell-mediated suppression of the antibody response.小鼠抗体应答调节中抗原特异性抑制性T细胞因子的特性。III. T细胞介导的抗体应答抑制的双基因控制。
J Exp Med. 1976 Jul 1;144(1):20-31. doi: 10.1084/jem.144.1.20.
9
Analysis of the cross-reactive immune suppression induced by the random copolymers L-glutamic acid50-L-tyrosine50 (GT), L-glutamic acid60-L-alanine40 and L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).对随机共聚物L-谷氨酸50-L-酪氨酸50（GT）、L-谷氨酸60-L-丙氨酸40和L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）诱导的交叉反应性免疫抑制的分析。
J Immunol. 1976 Nov;117(5 Pt 1):1603-7.
10
Inhibition of specific immune responses by feeding protein antigens.
Int Arch Allergy Appl Immunol. 1977;55(1-6):526-32. doi: 10.1159/000231966.

经口服抗原诱导产生的两种不同的抗原特异性抑制因子。

Two distinct antigen-specific suppressor factors induced by the oral administration of antigen.

作者信息

Mattingly J A, Kaplan J M, Janeway C A

出版信息

J Exp Med. 1980 Sep 1;152(3):545-54. doi: 10.1084/jem.152.3.545.

DOI:10.1084/jem.152.3.545
PMID:6774046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185915/
Abstract

The feeding of sheep erythrocytes (SRBC) to mice leads to the production of two distinct T cell-derived suppressor factors by spleen cells. Each has been characterized for specificity, genetic restrictions, and cellular interactions. Fraction I has a 60,000-75,000 mol wt, is specific for antigen, and is suppressive of primary in vitro anti-SRBC responses at all times. It is not restricted by major histocompabitility complex (MHC)- or Igh-linked genes, but it fails to suppress spleen cells derived from any strain of mouse with a B10 background. It acts on an Lyt-2+ T cell to increase suppressive activity. An antiserum has been prepared against this factor that reacts with other, unrelated T cell suppressor factors. Fraction II has an approximately 30,000-40,000 mol wt, is specific for antigen, and has a dual effect on in vitro anti-SRBC responses. On day 3 of culture, it leads to augmentation of the response, whereas at day 5 it suppresses the response. It is not restricted by MHC genes, but it is restricted by Igh-linked genets. It acts by activating an Ly-1 t cell to both help and induce feedback suppression. These factors, and the antisera prepared against them, should allow more precise dissection of the molecular pathways by which immunoregulatory cells communicate with one another.

摘要

给小鼠喂食绵羊红细胞（SRBC）会导致脾细胞产生两种不同的T细胞衍生抑制因子。每种因子都已针对特异性、遗传限制和细胞相互作用进行了表征。组分I的分子量为60,000 - 75,000道尔顿，对抗原具有特异性，并且在任何时候都能抑制体外抗SRBC的初次反应。它不受主要组织相容性复合体（MHC）或Igh连锁基因的限制，但不能抑制来自任何具有B10背景的小鼠品系的脾细胞。它作用于Lyt - 2 + T细胞以增加抑制活性。已经制备了针对该因子的抗血清，该抗血清与其他不相关的T细胞抑制因子发生反应。组分II的分子量约为30,000 - 40,000道尔顿，对抗原具有特异性，并且对体外抗SRBC反应具有双重作用。在培养的第3天，它会导致反应增强，而在第5天它会抑制反应。它不受MHC基因的限制，但受Igh连锁基因的限制。它通过激活Ly - 1 + T细胞来发挥辅助作用并诱导反馈抑制。这些因子以及针对它们制备的抗血清，应该能够更精确地剖析免疫调节细胞相互通讯的分子途径。