Nakagawa T, Ueda K, Nakajima H, Shimizu A
Department of Clinical Pathology, Osaka Medical College, Takatsuki.
Rinsho Byori. 1995 Jan;43(1):21-5.
Cold activation of complement (CA) is a phenomenon characterized by a low hemolytic complement activity in chilled serum. Cryoglobulin and RF have been reported as main causes of CA, and we previously reported the close association between CA and HCV infection in 21 CA patients. Therefore, we assayed CA, RF, cryoglobulin and anti-HCV antibody titers in 304 randomly selected patients with unknown diseases. CA was positive in 26 of the 304 patients, and among them, RF and/or cryoglobulin were found positive in 20 patients, and anti-HCV antibody were positive in all of them. RF was positive in 41 of the 304 patients. 37% of them were anti-HCV antibody positive and 63% were negative. Cryoglobulin was positive in 61 out of 304 patients. Anti-HCV antibody positivity was observed in 59 out of 304 patients, and all CA-positive cases were included in the anti-HCV antibody-titer-positive group. However, either RF or cryoglobulin positive patients were observed in the same degree in both anti-HCV antibody titer positive and negative groups. Therefore, RF or cryoglobulin is not considered the main cause of CA.
补体冷激活（CA）是一种在冷血清中溶血补体活性较低的现象。冷球蛋白和类风湿因子（RF）已被报道为CA的主要原因，并且我们之前报道了21例CA患者中CA与丙型肝炎病毒（HCV）感染之间的密切关联。因此，我们对304例随机选择的病因不明患者检测了CA、RF、冷球蛋白和抗HCV抗体滴度。304例患者中有26例CA呈阳性，其中20例患者RF和/或冷球蛋白呈阳性，且所有患者抗HCV抗体均呈阳性。304例患者中有41例RF呈阳性。其中37%抗HCV抗体呈阳性，63%呈阴性。304例患者中有61例冷球蛋白呈阳性。304例患者中有59例抗HCV抗体呈阳性，所有CA阳性病例均纳入抗HCV抗体滴度阳性组。然而，抗HCV抗体滴度阳性和阴性组中RF或冷球蛋白阳性患者的比例相同。因此，RF或冷球蛋白不被认为是CA的主要原因。
