Braun O H, Heine W E
Universitätskinderklinik Rostock.
Klin Padiatr. 1995 Jan-Feb;207(1):4-7. doi: 10.1055/s-2008-1046499.
The fecal microflora of the breast-fed infant consists of nearly 100% Bifidobacteria. The importance of this long-known and unique phenomenon is still not clearly understood. Likewise, the presence of lysozyme in the feces of breast-fed infants, which is administered in significant amounts with the human milk is not adequately known. New hints and hypotheses concerning digestion in ruminants are cited. In ruminants Lysozyme c functions as digestive enzyme in the rumen. Lysozyme causes lysis of the bacterial cell membrane leading to the release of bacterial contents i.e. proteins. The proteins synthesised in bacteria are the main source of nitrogen for ruminants. The hypothesis is established, that the enormous amounts of Bifidobacteria in the colon of the human newborn can be made of use in a similar way. The lysozyme in the colon of breast-fed infants leads to lysis of Bifidobacteria in connection with tryptic digestive enzymes, in turn leading to release of proteins and protein substances. It has recently been demonstrated that catabolic products of these proteins can be absorbed in the colon. The same group has shown that lysis of Bifidobacteria can take place in the presence of lysozyme in connection with trypsin.
母乳喂养婴儿的粪便微生物群几乎100%由双歧杆菌组成。这种早已为人所知的独特现象的重要性仍未得到清楚理解。同样，母乳喂养婴儿粪便中存在溶菌酶（其随母乳大量摄入）的情况也未得到充分了解。文中引用了有关反刍动物消化的新线索和假设。在反刍动物中，溶菌酶c在瘤胃中起消化酶的作用。溶菌酶会导致细菌细胞膜裂解，从而释放细菌内容物，即蛋白质。细菌合成的蛋白质是反刍动物氮的主要来源。由此提出一个假设，即人类新生儿结肠中大量的双歧杆菌也能以类似方式被利用。母乳喂养婴儿结肠中的溶菌酶与胰蛋白酶消化酶一起导致双歧杆菌裂解，进而导致蛋白质和蛋白质物质的释放。最近有研究表明，这些蛋白质的分解代谢产物可在结肠中被吸收。同一研究团队还表明，在溶菌酶和胰蛋白酶存在的情况下，双歧杆菌会发生裂解。
