Carman J S, Post R M, Buswell R, Goodwin F K
Am J Psychiatry. 1976 Oct;133(10):1181-6. doi: 10.1176/ajp.133.10.1181.
In order to test the efficacy of the pineal neurohumor melatonin on depression, the hormone was administered in varying doses to six moderately to severely depressed patients and two patients with Huntington's chorea in double-blind crossover study. Melatonin exacerbated symptoms of dysphoria in these patients, as well as causing a loss of sleep and weight and a drop in oral temperature. Melatonin increased cerebrospinal fluid 5-hydroxyindoleacetic acid and calcium in three of four patients studied. The authors discuss the implications of this finding.
为了测试松果体神经体液褪黑素对抑郁症的疗效，在一项双盲交叉研究中，对6名中度至重度抑郁症患者和2名亨廷顿舞蹈症患者给予了不同剂量的该激素。褪黑素加剧了这些患者的烦躁不安症状，还导致睡眠和体重下降以及口腔温度降低。在4名接受研究的患者中，有3名患者的脑脊液5-羟吲哚乙酸和钙含量增加。作者讨论了这一发现的意义。
