Cramer J A
Yale University School of Medicine, New Haven, Connecticut.
Neurology. 1995 Feb;45(2 Suppl 1):S25-8.
The key elements for enhancing patient compliance when prescribing are selecting the fewest number of daily doses (taking patient's other medications into consideration), scheduling when doses are to be taken, and helping the patient select an appropriate reminder or "cue." Developing reminder cues, such as clock time, meal time, or bathroom ritual, requires only a few minutes of careful planning to mesh with the patient's lifestyle. If one type of cue is not successful, another or combinations of cues are tried over time. Asking patients about their cues at each visit not only helps patients develop personalized cuing systems, but also reminds them that their physician has a consistent interest in the way they take their medication. Unfortunately, no single specific strategy will enhance compliance in all patients. Physicians have the greatest influence on medication compliance when they provide specific suggestions that fit into the patient's lifestyle.
选择最少的每日服药剂量（考虑患者正在服用的其他药物）、安排服药时间，以及帮助患者选择合适的提醒方式或“提示”。制定提醒提示，如时钟时间、用餐时间或日常洗漱习惯等，只需要几分钟的精心规划，就能与患者的生活方式相契合。如果一种提示方式不成功，随着时间的推移可以尝试另一种或多种提示方式的组合。每次就诊时询问患者关于他们的提示方式，不仅有助于患者建立个性化的提示系统，还能让他们意识到医生一直关注他们的用药方式。不幸的是，没有一种单一的特定策略能提高所有患者的依从性。当医生提供适合患者生活方式的具体建议时，对药物依从性的影响最大。
