Koerner S K, Hagstrom J W, Veith F J
Am Rev Respir Dis. 1976 Sep;114(3):575-9. doi: 10.1164/arrd.1976.114.3.575.
The accurate diagnosis of lung transplant rejection requires histologic examination of the grafted lung. Because transbronchial lung biopsy has been advocated as an effective diagnostic procedure for a variety of lung diseases, it was elected to assess this technique in rejecting transplanted lungs. Twenty-two dogs received allografts and underwent simultaneous lung biopsy by 3 techniques when signs of rejection occurred. Open lung biopsy was diagnostic of rejection in all instances. Transthoracic needle biopsy correlated with the open biopsy in 59 per cent of the cases. No specimen obtained by transbronchial lung biopsy provided sufficient material to permit fulfillment of the strict histologic criteria needed to diagnose allograft rejection. Although transbronchial lung biopsy is successful in many pulmonary infiltrative processes, it appears to be inadequate for the diagnosis of lung allograft rejection.
肺移植排斥反应的准确诊断需要对移植肺进行组织学检查。由于经支气管肺活检已被提倡作为多种肺部疾病的有效诊断方法，因此选择用该技术来评估移植肺发生排斥反应的情况。22只狗接受了同种异体移植，当出现排斥反应迹象时，通过3种技术同时进行肺活检。在所有病例中，开放性肺活检都能诊断出排斥反应。经胸针吸活检在59%的病例中与开放性活检结果相关。经支气管肺活检所获取的标本均未提供足够的材料以满足诊断同种异体移植排斥反应所需的严格组织学标准。虽然经支气管肺活检在许多肺部浸润性病变中是成功的，但它似乎不足以诊断肺同种异体移植排斥反应。
