Bardfeld P A, Yipintsoi T, Koerner S K, Crane R, Hagstrom J W, Veith F J
Surgery. 1976 Nov;80(5):575-80.
The uptake of 131I-fibrinogen in canine pulmonary allografts was compared to that in lung autografts or lungs with papain-induced unilateral hemorrhagic pneumonia. In addition to serial lung scans and the postmortem measurement of tissue radioactivity, all dogs had serial chest roentgenograms and histologic study of their lungs. All four animals in the allografted group had increased radioactive uptake on the side of the allograft lung at the same time as or slightly before radiographic abnormalities were evident. However, increases in lung radioactivity also occurred in animals with pneumonia or autografts at the time infiltrates were present. Thus the presence of increased lung scan activity, which occurs in rejecting lung allografts after the injection of 131I-fibrinogen, is not a specific index of pulmonary rejection.
将犬肺同种异体移植中131I-纤维蛋白原的摄取情况与肺自体移植或木瓜蛋白酶诱导的单侧出血性肺炎的肺中的摄取情况进行了比较。除了连续的肺部扫描和组织放射性的尸检测量外，所有犬均进行了连续的胸部X线片检查和肺部组织学研究。同种异体移植组的所有四只动物在同种异体移植肺侧的放射性摄取增加，与影像学异常出现的时间相同或略早。然而，在出现浸润时，肺炎或自体移植动物的肺部放射性也会增加。因此，注射131I-纤维蛋白原后在排斥的肺同种异体移植中出现的肺部扫描活性增加，并不是肺排斥的特异性指标。
