Chiaretti A, Castorina M, Tortorolo L, Piastra M, Polidori G
Sezione Autonoma di Terapia Intensiva Pediatrica, Università Cattolica del Sacro Cuore di Roma, Italia.
Pediatr Med Chir. 1994 Sep-Oct;16(5):489-90.
Vigabatrin is an irreversible inhibitor of gamma-aminobutyrate (Gaba) aminotransferase, producing an increase in Gaba concentrations in the brain. It may prove to be an important drug in the treatment of refractory epilepsy, but would be payed attention to behavioural changes noted in association with vigabatrin treatment. Behaviour disturbances, as psychosis, associated to vigabatrin are ben described in adult patients, while are uncommon in childhood. We report a case of acute psychosis occurred in a child in treatment with vigabatrin.
氨己烯酸是γ-氨基丁酸(GABA)转氨酶的不可逆抑制剂,可使脑内GABA浓度升高。它可能被证明是治疗难治性癫痫的一种重要药物,但需注意与氨己烯酸治疗相关的行为变化。与氨己烯酸相关的行为障碍,如精神病,在成年患者中已有描述,而在儿童中并不常见。我们报告了1例接受氨己烯酸治疗的儿童发生急性精神病的病例。