Xavier M, Bento M S, Pereira D P, De Almeida J M
Clínica Universitária da Faculdade de Ciências Médicas de Lisboa.
Acta Med Port. 2000 May-Jun;13(3):111-4.
Vigabatrin, a drug mainly used in the treatment of therapy-resistant epilepsy, has been associated to a large range of adverse effects, including acute psychotic disorders. The authors report the case of a 44-year-old patient with drug-resistant temporal lobe epilepsy that developed an acute psychotic episode about three weeks after initiating medication with vigabatrin. After the withdrawal of vigabatrin and the addition of an antipsychotic drug, the clinical picture improved promptly and the patient was discharged within a short period of time. The authors discuss the patient's diagnosis, the possible mechanisms of vigabatrin-associated psychosis and the therapeutic approach, stressing the questions that concern vigabatrin prescription and withdrawal.
氨己烯酸是一种主要用于治疗难治性癫痫的药物，它与一系列不良反应有关，包括急性精神障碍。作者报告了一例44岁的难治性颞叶癫痫患者，在用氨己烯酸治疗约三周后出现急性精神病发作。停用氨己烯酸并加用抗精神病药物后，临床症状迅速改善，患者在短时间内出院。作者讨论了患者的诊断、氨己烯酸相关精神病的可能机制及治疗方法，强调了与氨己烯酸处方和停药有关的问题。
