de Krom M C, Verduin N, Visser E, Kleijer M, Scholtes F, De Groen J H
Department of Neurology, Maastricht University Hospital, The Netherlands.
Seizure. 1995 Jun;4(2):159-62. doi: 10.1016/s1059-1311(95)80099-9.
Vigabatrin (gamma-vinyl-GABA or GVG) is an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), which is an enzyme responsible for gamma-aminobutyric acid (GABA) catabolism. Inhibition of GABA catabolism increases brain concentration of GABA, a neural inhibitor. GVG has been found to be a potent new anti-epileptic drug, especially in the treatment of refractory epilepsy, in particular of complex partial seizures. Three patients who developed a severe status epilepitus while on GVG treatment are reported. A possible proconvulsive effect of GVG is hypothesized, which might result from disinhibition in the nigro-collicular pathway due to increased GABA-levels.
氨己烯酸（γ-乙烯基-γ-氨基丁酸或GVG）是γ-氨基丁酸转氨酶（GABA-T）的不可逆抑制剂，GABA-T是一种负责γ-氨基丁酸（GABA）分解代谢的酶。抑制GABA分解代谢会增加神经抑制剂GABA在大脑中的浓度。已发现GVG是一种有效的新型抗癫痫药物，尤其在治疗难治性癫痫，特别是复杂部分性发作方面。本文报告了3例在接受GVG治疗时发生严重癫痫持续状态的患者。推测GVG可能具有促惊厥作用，这可能是由于GABA水平升高导致黑质-顶盖通路去抑制所致。
