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[骨髓移植前接受预处理方案患者的β2-微球蛋白和Tamm-Horsfall蛋白排泄情况]

[Excretion of beta-2-microglobulin and Tamm-Horsfall protein in patients undergoing a conditioning regimen before bone marrow transplantation].

作者信息

Franek E, Kokot F, Wojnar J, Wacławik A, Duława J, Wiecek A, Markiewicz M, Hołowiecki J

机构信息

Klinika Nefrologii Slaskiej Akademii Medycznej, Katowice.

出版信息

Pol Arch Med Wewn. 1994 Nov;92(5):381-6.

PMID:7885985
Abstract

UNLABELLED

This study aimed assess function of renal tubules in patients undergoing conditioning regimen before bone marrow transplantation. The examined group comprised 19 patients. 13 of them underwent autologuous bone marrow transplantation (ABMT), or autologuous peripheral blood stem cells transplantation (APBSCT). These patients were treated with Cyclophosphamide (Cy) (120 mg/kg), Etoposide (1.6-1.8 g/m2) and Carmustine (400-450 mg/m2). The remaining 6 patients underwent allogenic bone marrow transplantation (BMT). They were treated with Cy 200 mg/kg or with Cy 120 mg/kg and Busulfan 16 mg/kg (doses given are the total amount or respective drugs were administered during the whole conditioning regimen). Urinary excretion of beta-2MB and THP was assessed a) before the conditioning regimen was started, b) one day before completion of it, and c) one day before bone marrow transplantation. In ABMT/APBSCT patients urinary excretion of beta-2-MG was significantly higher before and during conditioning regimen as compared with baseline value (3309 +/- 1123.7 vs 3919 +/- 1417.8 vs 246.7 +/- 50.3 mg/24h, respectively, p < 0.05). Urinary excretion of THP in these patients was significantly higher only during the conditioning regimen (90.6 +/- 14.3 vs. 30.4 +/- 6.24 mg/24h, p < 0.0002). In BMT patients conditioning regimen was followed by similar but less marked changes of urinary excretion of beta-2-MG and THP as compared with ABMT/APBSCT patients.

CONCLUSIONS

  1. Conditioning regimen do influence significantly function of proximal and distal renal tubules. 2. The extent of disturbed function of renal tubules seems to depend on kind of medication that is given during the conditioning regimen.
摘要

未标注

本研究旨在评估骨髓移植前接受预处理方案的患者肾小管的功能。研究组包括19名患者。其中13名接受了自体骨髓移植（ABMT）或自体外周血干细胞移植（APBSCT）。这些患者接受了环磷酰胺（Cy）（120mg/kg）、依托泊苷（1.6 - 1.8g/m²）和卡莫司汀（400 - 450mg/m²）治疗。其余6名患者接受了异基因骨髓移植（BMT）。他们接受了200mg/kg的Cy或120mg/kg的Cy加16mg/kg的白消安治疗（所给剂量为整个预处理方案期间使用的每种药物的总量）。在以下时间点评估β - 2微球蛋白（β - 2MB）和THP的尿排泄量：a）在预处理方案开始前；b）在预处理方案完成前一天；c）在骨髓移植前一天。在ABMT/APBSCT患者中，与基线值相比，预处理方案前及预处理期间β - 2微球蛋白（β - 2 - MG）的尿排泄量显著更高（分别为3309±1123.7 vs 3919±1417.8 vs 246.7±50.3mg/24小时，p < 0.05）。这些患者中THP的尿排泄量仅在预处理期间显著更高（90.6±14.3 vs. 30.4±6.24mg/24小时，p < 0.0002）。与ABMT/APBSCT患者相比，BMT患者预处理方案后β - 2 - MG和THP的尿排泄量变化相似但不太明显。

结论

  1. 预处理方案确实会显著影响近端和远端肾小管的功能。2. 肾小管功能受干扰的程度似乎取决于预处理方案期间所使用的药物种类。

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