Yu M, Zhu Y Q
Dalian Municipal Central Hospital.
Zhonghua Nei Ke Za Zhi. 1991 Jun;30(6):354-6, 383.
Twenty-four hour urinary albumin (Alb) beta 2 microglobulin (beta 2m) and Tamm-Horsfall protein (THP) were measured by radioimmunoassay in 69 diabetics and 23 normal controls. The excretion of urinary Alb, beta 2m and THP in the patients with diabetic nephropathy was found to be different from that of normal controls. The abnormality of excretion of Alb, beta 2m and THP is particularly evident in the patients with clinical diabetic nephropathy. These results indicate that the renal lesions of diabetes mellitus exist not only in the glomeruli but also in the proximal and/or distal tubules. There was a significantly positive correlation between THP excretion and creatinine clearance (less than 127 ml/min/1.73m2). The findings suggest that the excretion of urinary THP is a valuable index for evaluating the damages of nephrons. It is believed that determination of urinary Alb, beta 2m and THP in diabetics is beneficial to early detection of the sites and degree of the renal lesions.
采用放射免疫分析法对69例糖尿病患者和23例正常对照者测定了24小时尿白蛋白（Alb）、β2微球蛋白（β2m）和Tamm-Horsfall蛋白（THP）。发现糖尿病肾病患者尿Alb、β2m和THP的排泄量与正常对照者不同。Alb、β2m和THP排泄异常在临床糖尿病肾病患者中尤为明显。这些结果表明，糖尿病的肾脏病变不仅存在于肾小球，也存在于近端和/或远端肾小管。THP排泄与肌酐清除率（小于127 ml/min/1.73m2）之间存在显著正相关。这些发现提示，尿THP排泄是评估肾单位损伤的一个有价值指标。据信，测定糖尿病患者尿Alb、β2m和THP有助于早期发现肾脏病变的部位和程度。
