Finch W T, Sawyers J L, Schenker S
Ann Surg. 1976 Jun;183(6):667-71. doi: 10.1097/00000658-197606000-00008.
This study is a double "blind" prospective evaluation of the efficacy of antibiotics (Ampicillin) in the treatment of acute alcohol-induced and idiopathic pancreatitis. Fifty-eight patients with acute pancreatitis were randomly divided into antibiotic and non-antibiotic treatment groups. The two groups were comparable clinically at the onset of the study and other than for antibiotics received identical therapy. The patients without antibiotics had a clinical course equal or slightly more favorable than the antibiotic treatment group in all parameters examined. These data indicate that prophylactic use of Ampicillin is not indicated in patients with routine acute alcohol-induced or idiopathic pancreatitis. The role of prophylactic antibiotics in patients with pancreatitis related to biliary calculi and those with more severe varieties of acute hemorrhagic or necrotizing pancreatitis remains to be more clearly defined.
本研究是一项关于抗生素（氨苄西林）治疗急性酒精性和特发性胰腺炎疗效的双“盲”前瞻性评估。58例急性胰腺炎患者被随机分为抗生素治疗组和非抗生素治疗组。在研究开始时，两组在临床上具有可比性，除抗生素外接受相同的治疗。在所有检查参数方面，未使用抗生素的患者临床病程与抗生素治疗组相当或略好。这些数据表明，对于常规急性酒精性或特发性胰腺炎患者，不建议预防性使用氨苄西林。预防性抗生素在胆石症相关性胰腺炎患者以及更严重的急性出血性或坏死性胰腺炎患者中的作用仍有待更明确界定。
