Nicholson Laura J
Scripps Clinic and Scripps Green Hospital, La Jolla, CA 92037, USA.
Curr Gastroenterol Rep. 2011 Aug;13(4):336-43. doi: 10.1007/s11894-011-0198-4.
Acute pancreatitis is a common cause of hospitalization and a major source of morbidity worldwide. When it is severe, and especially when it progresses to include necrosis of the pancreas, the risk of infection rises and mortality increases. Early reports suggested prophylactic antibiotics given in severe pancreatitis prevent infection and death. More recent clinical trials do not support this benefit, and meta-analyses on the topic offer conflicting recommendations. In this article, we evaluate the body of published literature examining the use of antibiotics as a preventive measure in acute pancreatitis. The highest quality, currently available data fail to support prophylactic use of antibiotics, which should be added to treatment regimens only where infection has been proven.
急性胰腺炎是全球住院治疗的常见病因和发病的主要来源。当病情严重时，尤其是发展为胰腺坏死时，感染风险上升且死亡率增加。早期报告表明，在重症胰腺炎中使用预防性抗生素可预防感染和死亡。但最近的临床试验并不支持这种益处，关于该主题的荟萃分析给出了相互矛盾的建议。在本文中，我们评估了已发表的关于在急性胰腺炎中使用抗生素作为预防措施的文献。目前可获得的最高质量数据不支持预防性使用抗生素，仅在已证实存在感染的情况下才应将其添加到治疗方案中。
