Krutvacho T, Chuansumrit A, Isarangkura P, Pintadit P, Hathirat P, Chiewsilp P
Department of Pediatrics, Pramongkutklao Hospital, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:169-73.
Fresh dry plasma (FDP) is a lyophilized form of fresh frozen plasma (FFP) which can be stored at 4 degrees C for one year. One bottle of FDP is prepared from 220 ml of FFP and contains FVIII: C 0.75 +/- 0.3 U/ml (mean +/- 1 SD). This study describes the clinical and laboratory response in 7 severe and 4 moderate hemophilia A patients. The age ranged from 7-17 years (mean +/- SD = 11.7 +/- 2.9 years). Either 12.4 ml/kg. FDP or 12.2 ml/kg FFP was transfused to the patients when they had bleeding episodes such as hemarthrosis, hematoma. 16 episodes of FDP and 12 episodes of FFP transfusion were studied. The bleeding could be effectively controlled by FDP or FFP except one patient who had physical therapy at 8 hours post FDP transfusion. The increment of FVIII:C was 14.1 +/- 5.3% at 30 minutes after FDP transfusion and 12.1 +/- 3.7% at 30 minutes after FFP transfusion. The recovery rate was 83.2 +/- 32.6% in FDP and 65.3 +/- 22.7% in FFP transfusion. The FVIII:C was decreased to 78.9 +/- 12.3%, 55.6 +/- 13% and 16.3% of the initial level at 2, 8, 24 hours after FDP transfusion respectively which were not statistically significantly different from FFP transfusion. No serious complication was found. FDP will replace FFP for the treatment of coagulation disorders such as hemophilia A. It is an useful alternative therapy which can be provided to the hemophiliac patients in the rural area in developing countries.
新鲜冻干血浆（FDP）是新鲜冰冻血浆（FFP）的冻干形式，可在4℃下储存一年。一瓶FDP由220ml FFP制备而成，含有FVIII:C 0.75±0.3U/ml（均值±1标准差）。本研究描述了7例重度和4例中度甲型血友病患者的临床和实验室反应。年龄范围为7至17岁（均值±标准差=11.7±2.9岁）。当患者出现关节积血、血肿等出血发作时，给他们输注12.4ml/kg的FDP或12.2ml/kg的FFP。研究了16次FDP输注和12次FFP输注。除了一名在FDP输注后8小时接受物理治疗的患者外，FDP或FFP均可有效控制出血。FDP输注后30分钟时FVIII:C的增加值为14.1±5.3%，FFP输注后30分钟时为12.1±3.7%。FDP输注的回收率为83.2±32.6%，FFP输注的回收率为65.3±22.7%。FDP输注后2、8、24小时，FVIII:C分别降至初始水平的78.9±12.3%、55.6±13%和16.3%，与FFP输注相比无统计学显著差异。未发现严重并发症。FDP将替代FFP用于治疗甲型血友病等凝血障碍。它是一种有用的替代疗法，可为发展中国家农村地区的血友病患者提供。
