Evans S G, Havlik I
Department of Experimental and Clinical Pharmacology, University of the Witwatersrand Medical School, Parktown, South Africa.
Trans R Soc Trop Med Hyg. 1994 Nov-Dec;88(6):683-6. doi: 10.1016/0035-9203(94)90229-1.
The interactions of amantadine with classical antimalarial drugs were evaluated against a chloriquine-resistant and a chloroquine-sensitive strain of Plasmodium falciparum in vitro. Amantadine potentiated the effect of chloroquine and quinine in both strains; it also potentiated the effect of mefloquine, halofantrine and primaquine in the chloroquine-resistant strain but had no effect in the chloroquine-sensitive strain. Amantadine had no effect on the response to pyrimethamine of either strain. Amantadine does not interfere with the activity of these compounds and may possibly enhance it.
在体外，针对氯喹抗性和氯喹敏感的恶性疟原虫株，评估了金刚烷胺与经典抗疟药物的相互作用。金刚烷胺增强了两种菌株中氯喹和奎宁的作用；它还增强了氯喹抗性菌株中甲氟喹、卤泛群和伯氨喹的作用，但对氯喹敏感菌株没有影响。金刚烷胺对两种菌株中乙胺嘧啶的反应均无影响。金刚烷胺不干扰这些化合物的活性，并且可能会增强其活性。
