Chawira A N, Warhurst D C
J Trop Med Hyg. 1987 Feb;90(1):1-8.
The activity of artemisinin (qinghaosu) in combination with some commonly-used antimalarial drugs was tested in vitro against a chloroquine-sensitive (NF54) and a chloroquine-resistant (K1) strain of Plasmodium falciparum. Both mefloquine and tetracycline showed marked potentiative synergism with artemisinin against both strains, whilst primaquine showed potentiation against K1. Combinations of artemisinin with pyrimethamine and with chloroquine were antagonistic. The results confirm observations on rodent malaria in vivo and indicate that the drug interactions seen were direct, through actions on the parasite, and not merely effects on drug distribution and metabolism in the mouse host.
对青蒿素（青蒿琥酯）与一些常用抗疟药物联合使用的活性进行了体外测试，以对抗氯喹敏感（NF54）和氯喹耐药（K1）的恶性疟原虫株。甲氟喹和四环素与青蒿素联合使用时，对这两种疟原虫株均显示出显著的增效协同作用，而伯氨喹对K1株显示出增效作用。青蒿素与乙胺嘧啶及氯喹的联合使用具有拮抗作用。这些结果证实了对啮齿动物体内疟疾的观察结果，并表明所观察到的药物相互作用是直接的，通过对寄生虫的作用，而不仅仅是对小鼠宿主中药物分布和代谢的影响。
