Siucińska E, Kossut M
Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
Acta Neurobiol Exp (Wars). 1994;54(4):345-54.
Vibrissae-to-barrels pathway is often used as a model for investigating CNS plasticity. We examined early changes in the cortical representation of row C of vibrissae in adult mice, following vibrissectomy removing all whiskers except row C. The changes of cortical representation of the spared row of vibrissae were mapped with 2-deoxyglucose autoradiography. We found that one day after lesion of vibrissal follicles the areal extent of cortical representation of row C is smaller than normally, but 7 days post lesion it increases significantly, by 60 to 90%, in all cortical layers. Additionally, seven days post-lesion the intensity of labelling was increased in cortical layer V. The result suggest that plasticity that can be observed with 2-deoxyglucose mapping in the barrel cortex is not due to unmasking of existing connection, but to reorganization of connectivity at many levels.
触须-桶状通路常被用作研究中枢神经系统可塑性的模型。我们研究了成年小鼠在切除除C排触须外的所有触须（触须切除术）后，C排触须在皮质表征中的早期变化。用2-脱氧葡萄糖放射自显影法绘制了留存触须排的皮质表征变化。我们发现，触须毛囊损伤一天后，C排触须的皮质表征面积范围比正常情况小，但损伤后7天，所有皮质层均显著增加，增幅为60%至90%。此外，损伤后7天，皮质第V层的标记强度增加。结果表明，用2-脱氧葡萄糖映射法在桶状皮质中观察到的可塑性并非由于现有连接的去掩蔽，而是由于多个层面连接的重组。
