金刚烷胺对药物性帕金森综合征的作用：血浆水平与疗效的关系。
Effect of amantadine on drug-induced parkisonism: relationship between plasma levels and effect.
作者信息
Pacifici G M, Nardini M, Ferrari P, Latini R, Fieschi C, Morselli P L
出版信息
Br J Clin Pharmacol. 1976 Oct;3(5):883-9. doi: 10.1111/j.1365-2125.1976.tb00642.x.
Abstract
Amantadine, administered at a dose of 200 mg/day, antagonized the extapyramidal symptomatology induced by neuroleptic drugs in fifteen psychiatric patients. Steady-state levels were reached within 4-7 days of treatment. Individual plasma levels ranged from 200-900 ng/ml. Apparent plasma half-lives varied from 10-28.5 h with an apparent VD of 200-400 litres. A significant relationship was found between the plasma levels of amantadine and the effects on the extrapyramidal symptomatology. The data suggest a direct effect of amantadine on dopaminergic receptors.
摘要
金刚烷胺以每日200毫克的剂量给药，可对抗15名精神病患者中由抗精神病药物引起的锥体外系症状。治疗4至7天内达到稳态水平。个体血浆水平在200 - 900纳克/毫升之间。表观血浆半衰期在10 - 28.5小时之间，表观分布容积为200 - 400升。发现金刚烷胺的血浆水平与对锥体外系症状的影响之间存在显著关系。数据表明金刚烷胺对多巴胺能受体有直接作用。
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本文引用的文献
1
Amantadine in the treatment of Parkinson's disease.
JAMA. 1969 May 19;208(7):1168-70.
2
[Action of amantadine in extrapyramidal syndromes caused by neuroleptics].
Sist Nerv. 1970 Sep-Oct;22(5):273-85.
3
[Drug therapy of Parkinson's disease with amantadine and levodopa].
Sist Nerv. 1970 Mar-Jun;22(2):126-43.
4
Increased synthesis and release of dopamine in the striatum of the rat after amantadine treatment.
Eur J Pharmacol. 1970;13(1):131-3. doi: 10.1016/0014-2999(70)90194-9.
5
The antiparkinson properties of amantadine in drug-induced parkinsonism.
J Clin Pharmacol New Drugs. 1971 May-Jun;11(3):211-4.
6
Dopamine and noradrenaline releasing action of amantadine in the central and peripheral nervous system: a possible mode of action in Parkinson's disease.
Eur J Pharmacol. 1971 Sep;16(1):27-38. doi: 10.1016/0014-2999(71)90053-7.
7
[Clinical study of amantadine in extrapyramidal syndromes caused by neuroleptics].
Minerva Med. 1971 Oct 31;62(82):4020-3.
8
The effect of amantadine on motor activity and catalepsy in rats.
Psychopharmacologia. 1972;24(2):296-307. doi: 10.1007/BF00403648.
9
Amantadine for Parkinson's disease.
Neurology. 1971 Sep;21(9):958-62. doi: 10.1212/wnl.21.9.958.
10
Comparison of amantadine, placebo, and levodopa in Parkinson's disease.
Neurology. 1974 Aug;24(8):715-20. doi: 10.1212/wnl.24.8.715.
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