Fann W E, Lake C R
Am J Psychiatry. 1976 Aug;133(8):940-3. doi: 10.1176/ajp.133.8.940.
Amantadine is a putative dopaminergic compound known to be therapeutically effective in idiopathic and postencephalitic Parkinson's disease. In a double-blind placebo-controlled crossover study of 39 psychiatric inpatients, amantadine and trihexyphenidyl were equally effective in treating drug-induced parkinsonism, and amantadine produced fewer and less severe side effects. The authors suggest that amantadine is an effective alternative to atropine-like agents, with fewer implications for long-term risk of tardive dyskinesia.
金刚烷胺是一种公认的多巴胺能化合物，已知对特发性和脑炎后帕金森病具有治疗效果。在一项针对39名精神科住院患者的双盲安慰剂对照交叉研究中，金刚烷胺和苯海索在治疗药物性帕金森综合征方面同样有效，且金刚烷胺产生的副作用更少、程度更轻。作者认为，金刚烷胺是阿托品样药物的有效替代品，对迟发性运动障碍的长期风险影响较小。
