Theofilopoulos A N
Dept of Immunology, Scripps Research Institute, La Jolla, CA 92037.
Immunol Today. 1995 Feb;16(2):90-8. doi: 10.1016/0167-5699(95)80095-6.
In this two-part series, Argyrios N. Theofilopoulos summarizes the current state of affairs in the field of autoimmunity. Part I integrates the collective mechanistic theories of autoimmune diseases. The most straightforward explanation to emerge with regard to organ-specific diseases is the concept that these are caused by inappropriate, yet conventional, immunological responses against self-antigens for which tolerance has never been established. A similar mechanism may be operative in systemic autoimmunity, but other abnormalities such as defects in the apoptosis machinery may also be invoked. Part II will address the genetic contributions predisposing to autoimmune syndromes.
在这个两部分的系列文章中，阿吉里奥斯·N·西奥菲洛普洛斯总结了自身免疫领域的当前状况。第一部分整合了自身免疫性疾病的集体机制理论。关于器官特异性疾病出现的最直接解释是，这些疾病是由针对自身抗原的不适当但常规的免疫反应引起的，而针对这些自身抗原从未建立过耐受性。类似的机制可能在全身性自身免疫中起作用，但也可能涉及其他异常情况，如细胞凋亡机制的缺陷。第二部分将探讨导致自身免疫综合征的遗传因素。
