Ridley R M, Baker H F, Annett L E, Dunnett S B, Torres E M, Fine A
Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Mol Neurobiol. 1994 Aug-Dec;9(1-3):207-23. doi: 10.1007/BF02816120.
The transplantation of neuronal tissue into the brains of patients with Parkinson's disease is already being assessed as an experimental treatment for the symptoms of this disease, and the possibility of using similar graft tissue to ameliorate the symptoms of other neurodegenerative diseases is being considered. In this context, a small number of transplant experiments have been carried out in monkeys with lesions of the central dopamine and cholinergic systems. These experiments make it possible to determine the optimum methods of transplantation in an animal whose brain is structurally more closely related to the human than that of the rat and to assess the behavioral consequences of transplantation on symptoms that either resemble very closely the symptoms seen in patients, or are of a complex cognitive nature and are therefore more difficult to measure in the rat. It is intended that these experiments will contribute to the development of better treatments for the neurodegenerative diseases, either by the use of transplantation as a clinical treatment, or by contributing to a better understanding of the mechanisms that normally maintain neuronal function and that fail in these diseases.
将神经组织移植到帕金森病患者大脑中，作为该疾病症状的一种实验性治疗方法，目前已在进行评估，同时也在考虑使用类似的移植组织来改善其他神经退行性疾病症状的可能性。在此背景下，已对患有中枢多巴胺能和胆碱能系统损伤的猴子进行了少量移植实验。这些实验能够确定在大脑结构比大鼠更接近人类的动物中进行移植的最佳方法，并评估移植对与患者所见症状非常相似或具有复杂认知性质因而在大鼠中更难测量的症状的行为影响。这些实验旨在通过将移植作为一种临床治疗方法，或者通过有助于更好地理解正常维持神经元功能但在这些疾病中失效的机制，为神经退行性疾病更好治疗方法的开发做出贡献。
