Frank S M, Raja S N
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Clin Auton Res. 1994 Oct;4(5):257-61. doi: 10.1007/BF01827431.
The effects of the cold pressor test on the coronary circulation have been clearly defined but the effects on the peripheral vasculature are less well understood. To measure the peripheral vasomotor response during cold pressor test perfusion in the upper extremity contralateral to the cold immersion was assessed by laser Doppler flowmetry and skin-surface temperature gradients. To identify the mechanism of vasoconstriction, cold pressor test was performed before and after the administration of phentolamine, an alpha-adrenoceptor antagonist. Vasoconstriction during cold pressor test was demonstrated by both skin-surface temperature gradients and by laser Doppler flowmetry. This vasoconstrictor response was significantly attenuated by the administration of phentolamine. The results demonstrate that the cold pressor test induces an alpha-adrenoceptor mediated vasoconstriction in the peripheral vasculature.
冷加压试验对冠状动脉循环的影响已得到明确界定，但对其对外周血管系统的影响了解较少。为了测量冷加压试验期间的外周血管运动反应，通过激光多普勒血流仪和皮肤表面温度梯度评估了与冷浸肢体对侧的上肢灌注情况。为了确定血管收缩的机制，在给予α-肾上腺素能受体拮抗剂酚妥拉明前后进行了冷加压试验。冷加压试验期间的血管收缩通过皮肤表面温度梯度和激光多普勒血流仪均得到证实。给予酚妥拉明后，这种血管收缩反应明显减弱。结果表明，冷加压试验在外周血管系统中诱导了α-肾上腺素能受体介导的血管收缩。
