Cummings M F, Steele P M, Mahar L J, Frewin D B, Russell W J
Cardiovasc Res. 1983 Apr;17(4):189-91. doi: 10.1093/cvr/17.4.189.
We studied the effects of a cold pressor test on the plasma catecholamine levels of ten patients undergoing coronary angiography, to determine whether the pressor changes were related to adrenergic activity. To investigate the relative contribution of adrenal medullary catecholamine release, we subjected two adrenalectomised volunteers to the same test. Arterial blood was assayed for dopamine (DA), adrenaline (A) and noradrenaline (NA). We found significant rises in the levels of all three catecholamines in the angiography patients, accompanied by a significant elevation in arterial blood pressure. In both the adrenalectomised patients a rise in blood pressure was seen but no significant rise in plasma catecholamines could be demonstrated. We postulate that although adrenal medullary catecholamine release occurs in response to the cold pressor test, the blood pressure elevation is independent of such adrenal activity. Sampling radial arterial blood may not reflect changes in plasma levels of peripherally released NA.
我们研究了冷加压试验对10名接受冠状动脉造影患者血浆儿茶酚胺水平的影响，以确定血压变化是否与肾上腺素能活性有关。为了研究肾上腺髓质儿茶酚胺释放的相对作用，我们让两名肾上腺切除的志愿者接受相同的试验。测定动脉血中的多巴胺（DA）、肾上腺素（A）和去甲肾上腺素（NA）。我们发现造影患者中所有三种儿茶酚胺水平均显著升高，同时动脉血压也显著升高。在两名肾上腺切除的患者中均观察到血压升高，但血浆儿茶酚胺未出现显著升高。我们推测，尽管肾上腺髓质儿茶酚胺释放是对冷加压试验的反应，但血压升高与此类肾上腺活动无关。采集桡动脉血可能无法反映外周释放的NA的血浆水平变化。
