Owsianowski M, Gollnick H, Siegert W, Schwerdtfeger R, Orfanos C E
Department of Dermatology, University Medical Center Benjamin Franklin, Berlin, Germany.
Bone Marrow Transplant. 1994 Nov;14(5):845-8.
A 43-year-old woman who had undergone allogeneic bone marrow transplant for chronic myeloid leukemia developed chronic GVHD. Despite cyclosporine A and low-dose glucocorticoids and later concomittent PUVA-therapy, chronic GVHD with severe sclerodermatous manifestations including joint contracture and liver damage progressed. The Karnofsky performance score dropped to under 50%. Extracorporeal photopheresis (ECP) instead of PUVA-therapy was started. To our knowledge, we here report the first case of successful treatment of extensive chronic GVHD with ECP.
一名43岁女性因慢性粒细胞白血病接受了异基因骨髓移植，发生了慢性移植物抗宿主病（GVHD）。尽管使用了环孢素A和低剂量糖皮质激素，后来又联合补骨脂素紫外线A光化学疗法（PUVA疗法），但伴有严重硬皮病表现（包括关节挛缩和肝损伤）的慢性GVHD仍在进展。卡诺夫斯基功能状态评分降至50%以下。于是开始采用体外光化学疗法（ECP）替代PUVA疗法。据我们所知，我们在此报告首例采用ECP成功治疗广泛性慢性GVHD的病例。
